PCR distribution

The distribution of mutations in an error prone library has been modelled in Sun (1995) based on the underlying principle of a PCR reaction. In the paper it is found that the distribution becomes more and more similar to a regular Possion and the two are virtually the same after 10 cycles. However, given that one most likely does not know what one's PCR efficiency is, using this formula may be dangerous. Whereas in reality getting a better estimate of the mean number of mutations may be more helpful.

Protein dropcaps

To make a webpage stylish does not mean that it cannot be biochemically themed. In fact, to can have both thanks to protein dropcaps! using the protein alphabet made by Prof. Mark Howarth in Nature Structural and Molecular Biology in May 2015(available Here) in combination with a wee JS script I wrote you can be a stylish biochemist. The script along with documentation is available in my GitHub page: https://github.com/matteoferla/protein_alphabet_dropcaps.

When a fully suicidal enzyme follows a second-order equation

A fully suicidal enzyme can follow an effective second-order rate law, but only in the appropriate concentration regime. The binding intermediate matters, as follows.