The art of blowing up protein

A segfault and NaN driven series of disconnected ideas, analyses and just plain silly posts about computational biochemistry, synthetic biology and microbiology.

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Showing posts with label alphafold2. Show all posts
Showing posts with label alphafold2. Show all posts
Saturday, 1 October 2022

Move aside coIP Westerns, ColabFold has got this!

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Recently AlphaFold2 released a new batch of models, this time covering all of the Trembl sequences in Uniprot, resulting in a h...
Sunday, 17 October 2021

Filling missing loops by cannibalising AlphaFold2

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I could not resist this Photoshop. But the process is not as dramatic and the results not as bad as Temple of Doom... If done right. AlphaFo...
Monday, 23 August 2021

Tweaking AlphaFold2 models with PyRosetta

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In a previous post I explored the pitfalls of an AlphaFold2 model from EBI. Here I thought I'd share some PyRosetta methods that may b...
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Tuesday, 27 July 2021

What to look out for with an AlphaFold2 model

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There is nothing more disheartening than telling someone "Sorry, I cannot help you with your protein, because no homologue structures o...
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Matteo Ferla
English/Italian computational biochemist at the University of Oxford in OPIG/XChem, formerly in Oxford BRC genomic medicine subtheme. All opinions my own.
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