tag:blogger.com,1999:blog-9015174234871442237.post6730850380813654453..comments2024-03-17T00:33:08.666-07:00Comments on The art of blowing up protein: What-if: Biosynthesis of deazaguanineMatteo Ferlahttp://www.blogger.com/profile/04090452288769979595noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-9015174234871442237.post-6673097285174334552021-08-13T02:49:28.562-07:002021-08-13T02:49:28.562-07:00I believe all examples of deazaguanine-based compo...I believe all examples of deazaguanine-based compounds in nature have a deazaguanine scaffold, but with a substituent on the novel carbon and do not go through an unsubstituted nucleobase —generally through the rather funky queuosine route. Here I was idly speculating how a direct route would work.Matteo Ferlahttps://www.blogger.com/profile/04090452288769979595noreply@blogger.comtag:blogger.com,1999:blog-9015174234871442237.post-43723739416226398482021-08-12T11:08:03.732-07:002021-08-12T11:08:03.732-07:00
Crippen, C. S., Lee, Y.-J., Hutinet, G., Shajaha...<br /> Crippen, C. S., Lee, Y.-J., Hutinet, G., Shajahan, A., Sacher, J. C., Azadi, P., Crécy-Lagard, V. de, Weigele, P. R., and Szymanski, C. M. (2019) Deoxyinosine and 7-Deaza-2-Deoxyguanosine as Carriers of Genetic Information in the DNA of Campylobacter Viruses. J Virol. 10.1128/jvi.01111-19<br /><br /><br /> Hutinet, G., Kot, W., Cui, L., Hillebrand, R., Balamkundu, S., Gnanakalai, S., Neelakandan, R., Carstens, A. B., Lui, C. F., Tremblay, D., Jacobs-Sera, D., Sassanfar, M., Lee, Y.-J., Weigele, P., Moineau, S., Hatfull, G. F., Dedon, P. C., Hansen, L. H., and Crécy-Lagard, V. de (2019) 7-Deazaguanine modifications protect phage DNA from host restriction systems. Nat Commun. 10, 5442<br /> peterwhttps://www.blogger.com/profile/09826220696700270577noreply@blogger.com